Phospholipids as metastases-targeting molecules using barcoding as a new research tool in liposome discovery
Dr Jeny Shklover (PhD - senior researcher; PRC) - Technion, Haifa, Israel (firstname.lastname@example.org)
Mor Sela (MSc student of chemical engineering; PRC) - Technion, Haifa, Israel (email@example.com)
Hadar Meltzer (BSc student of chemical engineering; PRC) - Technion, Haifa, Israel (firstname.lastname@example.org)
Yael Shammai (BSc student of chemical engineering; PRC ) - Technion, Haifa, Israel (email@example.com)
In nature, biological membranes consist of more than fifty percent of (phospho)lipids. These lipids play a central role in cell-cell interactions and tissue recognition. Despite their important biological role, drug delivery systems seldom take advantage of the lipid profile to improve targeting. In fact, in most cases proteins or sugar groups conjugated to the surface of lipid-based drug delivery systems are used to modulate cell uptake and biodistribution. In preliminary studies, we found that the lipid profile of liposomes is extremely important for determining the biological fate of liposomes to cells of breast cancer. In this project, we will study how lipids can be used to control tissue distribution, specifically to sites of breast cancer metastases in mice.
A combinatorial barcoding apparatus will be employed to study the biological fate of an array of liposomes to triple negative breast cancer metastasis. We expect that the study will generate fundamental insights into the interaction of lipids with biological tissues at the cellular and whole-body level.
Benefit for the community
This multidisciplinary research program combines approaches from life sciences, material engineering, and medicine to advance our therapeutic capabilities. This program will make scientific, clinical and social impact, yielding significant progress in the fields of Cancer Medicine basic research and application, and Lipid Nanotechnology, and by providing industry with new lipid particle fabrication capabilities.
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