Highly photosensitive phospholipid nanovesicles for near infrared light-triggered local anesthesia
Inadequate postoperative pain management is a common clinical issue for patients to optimize postoperative outcomes and enhance functional recovery after surgery.1) Locally injected anesthetics are effective in perioperative and other forms of acute pain, but they present fast systemic absorption leading to short duration and risk of systemic toxicity.2)3)
Herein, we propose a highly photosensitive nanovesicle to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, which consists of gold nanoparticles attached to mechanoresponsive liposomes (Figure 1). The mechanoresponsive liposomes will be made from an artificial 1,3-diamidophospholipid. A local anesthetic, tetrodotoxin will be encapsulated in the liposome. Near-infrared (NIR) laser pulses can activate the gold-coating to create nanomechanical stress to break the packing defects, leading to the efficient cargo release.4)5) We will use two models to test the infiltration local anesthesia and regional anesthesia over three days at different laser pulses and energy. The outcome of this study will not only develop a new kind of photosensitive phospholipid liposome, but also contribute to the on-demand, personalized local anesthesia and pain management.
Benefit for the community
This work aims to develop new highly photosensitive liposomal local anesthetics for adjustable on-demand postoperative pain management. This work has several benefits for the scientific community and broader phospholipid industry.
- Firstly, the efficient photo-release from this gold-coated mechanoresponsive nanovesicles provides better understanding of this innovative lipid molecule and the membrane structure.
- Secondly, the strategy of gold coating to make near infrared (NIR) photosensitive liposomes provides a new way to prepare externally triggered drug delivery systems.
Optimal postoperative pain management: redefining the role for opioids
Lancet 393, 1483-1485
The history and progress of local anesthesia: multiple approaches to elongate the action
J. Anesth. 32, 632-636
Externally triggered patient-controlled local anesthesia
Pain Manag. 8, 313-315
Ultrafast near-infrared light-triggered intracellular uncaging to probe cell signaling
Adv. Funct. Mater. 27, 1605778
Near-infrared light triggered-release in deep brain regions using ultra-photosensitive nanovesicles
Angew. Chem. Int. Ed. - published online