Lipid nanovectors to use non-coding RNA oligonucleotides in glioblastoma in combination with standard therapy – part II

Prof. Dr. G. De Rosa1), University Frederico II Naples/Italy

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1.

Prof. Dr. Giuseppe De RosaDepartment of Pharmacy, University Federico II of Naples, Via Domenico Montensanto 49, 80131 Naples, Italy

People involved

Prof. Giuseppe De Rosa (gderosa@unina.it) and Dr. Virginia Campani - Department of Pharmacy, University Federico II of Naples

Prof. Michele Caraglia, Dr. Silvia Zappavigna, and Dr. Marianna Abate - Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy

Dr. Carlo Leonetti and Dr. Manuela Porru - Department of Research, Diagnosis and Innovate Technologies, Regina Elena National Cancer, Rome, Italy

Abstract

This is a follow-up study. Please refer to the first project.

For short, this research activity should provide the proof-of-principle for using SANPs as delivery system for miRNA in the treatment of brain tumors, thus supporting the further studies.

Results/Outcome

Will be added as soon as available.

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Contact

Publications derived from the project:
1.
Campani V, Zappavigna S, Scotti L, Abate M, Porru M, Leonetti C, Caraglia M, De Rosa G, 2020
Hybrid lipid self-assembling nanoparticles for brain delivery of microRNA
Int. J. Pharm. 588, 119693
2.
Abate M, Porru M, Campani V, Leonetti C, Nele V, Di Paola R, De Martino M, Russo M, Tathode M, Cossu AM, Bocchetti M, Angelillo A, Ianniello M, Petrillo N, Savarese G, Monica RD, Chiariotti L, Addeo R, Caraglia M, De Rosa G, Zappavigna S, 2024
Self-assembling nanoparticles for delivery of miR-603 and miR-221 in glioblastoma as a new strategy to overcome resistance to temozolomide
J Control Release 377, 458-469
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