Phospholipids in Literature and Publications

Here you can find a selection of useful basic literature on phospholipids as well as publications that are  the results of the funded projects. For the latter, please select "PRC-Projects".

You can further narrow down the number of publications by selecting the format of the publication (article, review, poster, ...), the category (parenteral, oral, dermal, ...) and/or the aggregates described in the therein (liposomes, lipid nanoparticles, etc.).

ArticleGenerating Large Numbers of Pancreatic Microtumors on Alginate-Gelatin Hydrogels for Quantitative Imaging of Tumor Growth and Photodynamic Therapy Optimization

Carigga Gutierrez NM, Le Clainche T, Coll JL, Sancey L, Broekgaarden M, 2022. Methods Mol. Biol. 2451, 91-105.

ArticleSynthetic cells with self-activating optogenetic proteins communicate with natural cells

Adir O, Albalak MR, Abel R, Weiss LE, Chen G, Gruber A, Staufer O, Kurman Y, Kaminer I, Shklover J, Shainsky-Roitman J, Platzman I, Gepstein L, Shechtman Y, Horwitz BA, Schroeder A, 2022. Nat. Commun. 13, 2328.

ArticleOptimizing the Pharmacological and Optical Dosimetry for Photodynamic Therapy with Methylene Blue and Nanoliposomal Benzoporphyrin on Pancreatic Cancer Spheroids

Le Clainche T, Carigga Gutierrez NM, Pujol-Solé N, Coll J-L, Broekgaarden M, 2022 . Onco 2, 19-33.

ArticleCerosomes as skin repairing agent: Mode of action studies with a model stratum corneum layer at liquid/air and liquid/solid interfaces

Strati F, Mukhina T, Neubert RHH, Opalka L, Hause G, Schmelzer CEH, Menzel M, Brezesinski G, 2022. BBA Advances 2, 100039.

ArticleLecithin-based nanoemulsions of traditional herbal wound healing agents and their effect on human skin cells

Vater C, Bosch L, Mitter A, Gols T, Seiser S, Heiss E, Elbe-Burger A, Wirth M, Valenta C, Klang V, 2022. Eur. J. Pharm. Biopharm. 170, 1-9.

ArticleTargeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases

Kaduri M, Sela M, Kagan S, Poley M, Abumanhal-Masarweh H, Mora-Raimundo P, Ouro A, Dahan N, Hershkovitz D, Shklover J, Shainsky-Roitman J, Buganim Y, Schroeder A, 2021. Sci. Adv. 7, eabj5435.

ArticleCD169 Defines Activated CD14(+) Monocytes With Enhanced CD8(+) T Cell Activation Capacity

Affandi AJ, Olesek K, Grabowska J, Nijen Twilhaar MK, Rodríguez E, Saris A, Zwart ES, Nossent EJ, Kalay H, de Kok M, Kazemier G, Stöckl J, van den Eertwegh AJM, de Gruijl TD, Garcia-Vallejo JJ, Storm G, van Kooyk Y, den Haan JMM, 2021. Front. Immunol. 12, 697840.

ArticleIncorporation of Molecular Reorientation into Modeling Surface Pressure-Area Isotherms of Langmuir Monolayers

Agudelo J, Bossa GV, May S, 2021. Molecules 26, 4372.

ArticleMembrane-water partitioning – Tackling the challenges of poorly soluble drugs using chaotropic co-solvents

Nasswetter LC, Fischer M, Scheidt HA, Heerklotz H, 2021. Biophys. Chem. 277, 106654.

ArticleMimicking Pathogens to Augment the Potency of Liposomal Cancer Vaccines

Nijen Twilhaar MK, Czentner L, van Nostrum CF, Storm G, den Haan JMM, 2021. Pharmaceutics 13, 954.

ArticlePhospholipid-coated targeted microbubbles for ultrasound molecular imaging and therapy

Langeveld SAG, Meijlink B, Kooiman K, 2021. Curr. Opinion Chem. Biol. 63, 171-179.

ArticleHow to Achieve High Encapsulation Efficiencies for Macromolecular and Sensitive APIs in Liposomes

Ullmann K, Leneweit G, Nirschl H, 2021. Pharmaceutics 13, 691.

ArticleEncapsulation of Hydrophilic Compounds in Small Extracellular Vesicles: Loading Capacity and Impact on Vesicle Functions

Hettich BF, Bader JJ, Leroux JC, 2021. Adv. Healthc. Mater., e2100047.

Article, Clinical TrialChanges in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy

Vater C, Apanovic A, Riethmüller C, Litschauer B, Wolzt M, Valenta C, Klang V, 2021. Pharmaceutics 13, 436.

ArticleLiposome induction of CD8(+) T cell responses depends on CD169(+) macrophages and Batf3-dependent dendritic cells and is enhanced by GM3 inclusion

Grabowska J, Affandi AJ, van Dinther D, Nijen Twilhaar MK, Olesek K, Hoogterp L, Ambrosini M, Heijnen DAM, Klaase L, Hidalgo A, Asano K, Crocker PR, Storm G, van Kooyk Y, den Haan JMM, 2021. J. Controlled Release 331, 309-320.

ArticleTowards the Development of Long Circulating Phosphatidylserine (PS)- and Phosphatidylglycerol (PG)-Enriched Anti-Inflammatory Liposomes: Is PEGylation Effective?

Klein ME, Rieckmann M, Sedding D, Hause G, Meister A, Mäder K, Lucas H, 2021. Pharmaceutics 13, 282.

ArticleDebye-Hückel Free Energy of an Electric Double Layer with Discrete Charges Located at a Dielectric Interface

Bossa GV, May S, 2021. Membranes 11, 129.

ArticleThe Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles

Langeveld SAG, Beekers I, Collado-Lara G, van der Steen AFW, de Jong N, Kooiman K, 2021. Pharmaceutics 13, 119.

ArticleLiposomal Nanovaccine Containing α-Galactosylceramide and Ganglioside GM3 Stimulates Robust CD8(+) T Cell Responses via CD169(+) Macrophages and cDC1

Grabowska J, Stolk DA, Nijen Twilhaar MK, Ambrosini M, Storm G, van der Vliet HJ, de Gruijl TD, van Kooyk Y, den Haan JMM, 2021. Vaccines (Basel) 9, 56.

ArticleAnalytical profiling and stability evaluation of liposomal drug delivery systems: a rapid UHPLC-CAD-based approach for phospholipids in research and quality control

Weber F, Rahnfeld L, Luciani P, 2020. Talanta 220, 121320.

ArticleOptimization of Liposomes for Antigen Targeting to Splenic CD169(+) Macrophages

Nijen Twilhaar MK, Czentner L, Grabowska J, Affandi AJ, Lau CYJ, Olesek K, Kalay H, van Nostrum CF, van Kooyk Y, Storm G, den Haan J, 2020. Pharmaceutics 12, 1138.

ArticleInfluence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Mwiiri FK, Daniels R, 2020. Molecules 25, 4799.

ArticleSelective tumor antigen vaccine delivery to human CD169(+) antigen-presenting cells using ganglioside-liposomes

Affandi AJ, Grabowska J, Olesek K, Lopez Venegas M, Barbaria A, Rodríguez E, Mulder PPG, Pijffers HJ, Ambrosini M, Kalay H, O’Toole T, Zwart ES, Kazemier G, Nazmi K, Bikker FJ, Stöckl J, van den Eertwegh AJM, de Gruijl TD, Storm G, van Kooyk Y, den Haan JMM, 2020. Proc. Natl. Acad. Sci. U. S. A. 117, 27528-27539.

ArticleSuitability of phosphatidylcholine-based formulations for liquid filling in hard capsules

Grüne L, Bunjes H, 2020. Eur. J. Pharm. Sci. 153, 105470.

ArticleOptimized Birch Bark Extract-Loaded Colloidal Dispersion Using Hydrogenated Phospholipids as Stabilizer

Mwiiri FK, Daniels R, 2020. Pharmaceutics 12, 832.

ArticleSpontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

Farzan M, Quebatte G, Strittmatter K, Hilty FM, Schoelkopf J, Huwyler J, Puchkov M, 2020. Pharmaceutics 12, 777.

ArticleElectrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract

Mwiiri FK, Brandner JM, Daniels R, 2020. Pharmaceutics 12, 770.

ArticleLight-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System

Kari OK, Tavakoli S, Parkkila P, Baan S, Savolainen R, Ruoslahti T, Johansson NG, Ndika J, Alenius H, Viitala T, Urtti A, Lajunen T, 2020. Pharmaceutics 12, 763.

Article, Clinical TrialHybrid lipid self-assembling nanoparticles for brain delivery of microRNA

Campani V, Zappavigna S, Scotti L, Abate M, Porru M, Leonetti C, Caraglia M, De Rosa G, 2020. Int. J. Pharm. 588, 119693.

ArticleAssessment of the applicability of HLB values for natural phospholipid emulsifiers for preparation of stable emulsions

Otto F, van Hoogevest P, Syrowatka F, Heinl V, Neubert RHH, 2020. Pharmazie 75, 365-370.

ArticleThe Beauty of Asymmetric Membranes: Reconstitution of the Outer Membrane of Gram-Negative Bacteria

Paulowski L, Donoghue A, Nehls C, Groth S, Koistinen M, Hagge SO, Böhling A, Winterhalter M, Gutsmann T, 2020. Front. Cell Dev. Biol. 8, 586.

ArticlePhosphatidylserine (PS)- and phosphatidylglycerol-(PG)-enriched mixed micelles (MM): a new nano-drug delivery system with anti-inflammatory potential?

Klein ME, Rieckmann M, Lucas H, Meister A, Loppnow H, Mäder K, 2020. Eur. J. Pharm. Sci., 105451.

ArticleSynthesis and aggregation behaviour of single-chain, 1,32-alkyl-branched bis(phosphocholines) – part 2: lateral chain length triggers self-assembling from sheets to fibres to vesicles

Gruhle K, Tuchtenhagen M, Müller S, Hause G, Meister A, Drescher S, 2020. Org. Biomol. Chem. 18, 3585-3598.

ArticleSaddle-curvature instability of lipid bilayer induced by amphipathic peptides: a molecular model

Downing R, Volpe Bossa G, May S, 2020. Soft Matter 16, 5032-5043.

ArticleEffects of lecithin-based nanoemulsions on skin: Short-time cytotoxicity MTT and BrdU studies, skin penetration of surfactants and additives and the delivery of curcumin

Vater C, Hlawaty V, Werdenits P, Cichon MA, Klang V, Elbe-Burger A, Wirth M, Valenta C, 2020. Int. J. Pharm. 580, 119209.

ArticleSelf-dispersing formulations for the delivery of poorly soluble drugs – Miscibility of phosphatidylcholines with oils and fats

Grüne L, Bunjes H, 2020. Eur. J. Pharm. Biopharm. 151, 209-219.

ArticleLigand Distribution and Lipid Phase Behavior in Phospholipid-Coated Microbubbles and Monolayers

Langeveld SAG, Schwieger C, Beekers I, Blaffert J, van Rooij T, Blume A, Kooiman K, 2020. Langmuir 36, 3221-3233.

ArticleAdsorption process for phospholipids of different chain lengths at a fluorocarbon/water interface studied by Du Noüy ring and spinning drop

Ullmann K, Poggemann L, Nirschl H, Leneweit G, 2020. Colloid Polym. Sci. 298, 407-417.

ArticleInfluence of spontaneous curvature on the line tension of phase-coexisting domains in a lipid monolayer: A Landau-Ginzburg model

Rufeil Fiori E, Downing R, Bossa GV, May S, 2020. J. Chem. Phys. 152, 054707.

ArticleThe role of liposomes in clinical nanomedicine development. What now? Now what?

Crommelin DJA, van Hoogevest P, Storm G, 2020. J. Controlled Release 318, 256-263.

ArticleUltrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization

de Matos MBC, Deckers R, van Elburg B, Lajoinie G, de Miranda BS, Versluis M, Schiffelers R, Kok RJ, 2019. Front. Pharmacol. 10, 1463.

ArticleBolalipid-Doped Liposomes: Can Bolalipids Increase the Integrity of Liposomes Exposed to Gastrointestinal Fluids?

Müller S, Gruhle K, Meister A, Hause G, Drescher S, 2019. Pharmaceutics 11, 646.

ArticlePhosphatidylserine (PS) and phosphatidylglycerol (PG) nanodispersions as potential anti-inflammatory therapeutics: Comparison of in vitro activity and impact of pegylation

Klein ME, Mauch S, Rieckmann M, Martinez DG, Hause G, Noutsias M, Hofmann U, Lucas H, Meister A, Ramos G, Loppnow H, Mäder K, 2020. Nanomedicine 23, 102096.

ArticleCollagenase Nanoparticles Enhance the Penetration of Drugs into Pancreatic Tumors

Zinger A, Koren L, Adir O, Poley M, Alyan M, Yaari Z, Noor N, Krinsky N, Simon A, Gibori H, Krayem M, Mumblat Y, Kasten S, Ofir S, Fridman E, Milman N, Lubtow MM, Liba L, Shklover J, Shainsky-Roitman J, Binenbaum Y, Hershkovitz D, Gil Z, Dvir T, Luxenhofer R, Satchi-Fainaro R, Schroeder A, 2019. ACS Nano 13, 11008-11021.

ArticleRole of Transmembrane Proteins for Phase Separation and Domain Registration in Asymmetric Lipid Bilayers

Bossa GV, Gunderson S, Downing R, May S, 2019. Biomolecules 9, 303.

ArticleTailoring the lipid composition of nanoparticles modulates their cellular uptake and affects the viability of triple negative breast cancer cells

Abumanhal-Masarweh H, da Silva D, Poley M, Zinger A, Goldman E, Krinsky N, Kleiner R, Shenbach G, Schroeder JE, Shklover J, Shainsky-Roitman J, Schroeder A, 2019. J. Controlled Release 307, 331-341.

ArticleCombined Confocal Microscope and Brandaris 128 Ultra-High-Speed Camera

Beekers I, Lattwein KR, Kouijzer JJP, Langeveld SAG, Vegter M, Beurskens R, Mastik F, Verduyn Lunel R, Verver E, van der Steen AFW, de Jong N, Kooiman K, 2019. Ultrasound Med. Biol. 45, 2575-2582.

ArticleCytotoxicity of lecithin-based nanoemulsions on human skin cells and ex vivo skin permeation: Comparison to conventional surfactant types

Vater C, Adamovic A, Ruttensteiner L, Steiner K, Tajpara P, Klang V, Elbe-Bürger A, Wirth M, Valenta C, 2019. Int. J. Pharm. 566, 383-390.

ArticleEvaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for Oral Controlled Delivery of Water-Soluble Drugs

Kolbina M, Schulte A, van Hoogevest P, Körber M, Bodmeier R, 2019. AAPS PharmSciTech 20, 159.

ArticleLoading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

Farzan M, Roth R, Quebatte G, Schoelkopf J, Huwyler J, Puchkov M, 2019. Pharmaceutics 11, 32.

ArticleSodium bicarbonate nanoparticles modulate the tumor pH and enhance the cellular uptake of doxorubicin

Abumanhal-Masarweh H, Koren L, Zinger A, Yaari Z, Krinsky N, Kaneti G, Dahan N, Lupu-Haber Y, Suss-Toby E, Weiss-Messer E, Schlesinger-Laufer M, Shainsky-Roitman J, Schroeder A, 2019. J. Controlled Release 296, 1-13.

ArticlePhysicochemical characterization of natural phospholipid excipients with varying PC content

Otto F, Brezesinski G, van Hoogevest P, Neubert RHH, 2018. Colloids Surf. A 558, 291-296.

ArticleMixing behaviour of bilayer-forming phosphatidylcholines with single-chain alkyl-branched bolalipids: effect of lateral chain length

Müller S, Kind M, Gruhle K, Hause G, Meister A, Drescher S, 2019. Biophys. Chem. 244, 1-10.

Article, Clinical TrialNLC versus nanoemulsions: Effect on physiological skin parameters during regular in vivo application and impact on drug penetration

Wolf M, Klang V, Stojcic T, Fuchs C, Wolzt M, Valenta C, 2018. Int. J. Pharm. 549, 343-351.

ArticleThermosensitive liposomes for triggered release of cytotoxic proteins

de Matos MBC, Beztsinna N, Heyder C, Fens M, Mastrobattista E, Schiffelers RM, Leneweit G, Kok RJ, 2018. Eur. J. Pharm. Biopharm. 132, 211-221.

ArticleMonoacyl-phosphatidylcholine based drug delivery systems for lipophilic drugs: Nanostructured lipid carriers vs. nano-sized emulsions

Wolf M, Reiter F, Heuser T, Kotisch H, Klang V, Valenta C, 2018. J. Drug Delivery Sci. Technol. 46, 490-497.

ArticleMixing behaviour of asymmetrical glycerol diether bolalipids with saturated and unsaturated phosphatidylcholines

Müller S, Meister A, Otto C, Hause G, Drescher S, 2018. Biophys. Chem. 238, 39-48.

ArticleSynthesis and aggregation behaviour of single-chain, 1,32-alkyl branched bis(phosphocholines): effect of lateral chain length

Gruhle K, Müller S, Meister A, Drescher S, 2018. Org. Biomol. Chem. 16, 2711-2724.

ArticleInvestigations of the influence of liposome composition on vesicle stability and drug transfer in human plasma: a transfer study

Holzschuh S, Kaess K, Bossa GV, Decker C, Fahr A, May S, 2018. J. Liposome Res. 28, 22-34.

ArticleImpact of Headgroup Asymmetry and Protonation State on the Aggregation Behavior of a New Type of Glycerol Diether Bolalipid

Drescher S, Otto C, Müller S, Garamus VM, Garvey CJ, Grünert S, Lischka A, Meister A, Blume A, Dobner B, 2018. Langmuir 34, 4360-4373.

ArticleRock the nucleus: significantly enhanced nuclear membrane permeability and gene transfection by plasmonic nanobubble induced nanomechanical transduction

Li X, Kang P, Chen Z, Lal S, Zhang L, Gassensmith JJ, Qin Z, 2018. Chem. Commun. 54, 2479-2482.

ArticleStudy on the in situ aggregation of liposomes with negatively charged phospholipids for use as injectable depot formulation

Rahnfeld L, Thamm J, Steiniger F, van Hoogevest P, Luciani P, 2018. Colloids Surf. B 168, 10-17.

ArticleAcetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

Glatzel DK, Koeberle A, Pein H, Löser K, Stark A, Keksel N, Werz O, Müller R, Bischoff I, Fürst R, 2018. J. Lipid Res. 59, 298-311.

ArticleInstability Mechanisms of Water-in-Oil Nanoemulsions with Phospholipids: Temporal and Morphological Structures

Sommerling J-H, de Matos MBC, Hildebrandt E, Dessy A, Kok RJ, Nirschl H, Leneweit G, 2018. Langmuir 34, 572-584.

ArticleTargeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer

Binnemars-Postma KA, Bansal R, Storm G, Prakash J, 2018. FASEB J. 32, 969-978.

ArticleAn Asymmetrical Glycerol Diether Bolalipid with Protonable Phosphodimethylethanolamine Headgroup: The Impact of pH on Aggregation Behavior and Miscibility with DPPC

Markowski T, Müller S, Dobner B, Meister A, Blume A, Drescher S, 2017. Polymers 9, 573.

ArticleMonoacyl-phosphatidylcholine nanostructured lipid carriers: Influence of lipid and surfactant content on in vitro skin permeation of flufenamic acid and fluconazole

Wolf M, Klang V, Halper M, Stix C, Heuser T, Kotisch H, Valenta C, 2017. J. Drug Delivery Sci. Technol. 41, 419-430.

ArticleSaturated phosphatidylcholine as matrix former for oral extended release dosage forms

Kolbina M, Bodmeier R, Körber M, 2017. Eur. J. Pharm. Sci. 108, 86-92.

ArticleVitamin A regulates Akt signaling through the phospholipid fatty acid composition

Pein H, Koeberle SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A, 2017. FASEB J. 31, 4566-4577.

ArticleNanomedicine Strategies to Target Tumor-Associated Macrophages

Binnemars-Postma KA, Storm G, Prakash J, 2017. Int. J. Mol. Sci. 18, 979.

ArticleUltrafast Near-Infrared Light-triggered Intracellular Uncaging to Probe Cell Signaling

Li X, Che Z, Mazhar K, Price TJ, Qin Z, 2017. Adv. Funct. Mater. 27.

ArticleDistribution of phospholipid based formulations in the skin investigated by combined ATR-FTIR and tape stripping experiments

Wolf M, Halper M, Pribyl R, Baurecht D, Valenta C, 2017. Int. J. Pharm. 519, 198-205.

ArticleDifferential uptake of nanoparticles by human M1 and M2 polarized macrophages: protein corona as a critical determinant

Binnemars-Postma KA, ten Hoopen HWM, Storm G, Prakash J, 2016. Nanomedicine 11, 2889-2902.

ArticleStearoyl-CoA desaturase-1 and adaptive stress signaling

Koeberle A, Löser K, Thürmer M, 2016. Biochim. Biophys. Acta 1861, 1719-1726.

ArticleAnimal Models of Complement-Mediated Hypersensitivity Reactions to Liposomes and Other Lipid-Based Nanoparticles

Szebeni J, Alving CR, Rosivall L, Bünger R, Baranyi L, Bedöcs P, Tóth M, Barenholz Y, 2007. J. Liposome Res. 17, 107-117.

ArticleOral acute toxicity of polyenylphosphatidylcholine (PPC) in rats

Krosnjar S, Todić M, Bakić S, Begović B, Zulić I, Vehabović M, 2005. Bosn. J. Basic Med. Sci. 5, 63-68.

ArticleFractionation of Soybean Phospholipids by High-Performance Liquid Chromatography with an Evaporative Light-Scattering Detector

Wang T, Hammond EG, Cornette JL, Fehr WR, 1999. JAOCS 76:1313-1321.

ArticleBestimmung der Phospholipide durch HPLC. DGF Einheitsmethoden

Bonekamp A, Fiebig H-J, 1999

ArticleDetermination of Bacterial Endotoxins in Phospholipids by Means of the Limulus Amoebocyte Lysate Test

Stueben J, Arseven K, Rebmann B, 1997. Pharm. Ind. 59:895-898.

ArticleA Chemometric Strategy for the Classification of Lecithins According to Process Performance

Kaufmann P, Olsson U, Herslof BG, 1990. JAOCS 67:537-540.

ArticleA modified procedure for thin-layer chromatography of phospholipids

Allan D, Crockcroft S, 1982. J Lip Res 23:1373-1374.

ArticleAnalysis of Soybean Lecithin by Thin Layer and Analytical Liquid Chromatography

Erdahl NL, Stolyhwo A, Privett OS, 1973. JOACS 50, 513–515.

ArticleA Comparison of the Effects of Saturated and Polyunsaturated Lysolecithin Fractions on Platelet Aggregation and Erythrocyte Sedimentation

Besterman EMM, Gillett MPT, 1972. Artheriosclerosis. 16:89-94.

ArticleAcute and Subacute Toxicities of the Essential Phospholipids Injection

Nagasaka Y, Inai S, Osumi Y, Takori S, Shimamoto K, 1969. Pharmacomet 3:45-56.