Workshop on phospholipids, an important determinant of oral drug absorption
- How important are they for a successful development of biorelevant in vitro dissolution and permeation assays?
- How can they be used in formulation development to improve the oral bioavailability of drugs?
Exhibition Center Nuremberg, NürnbergMesse, Messezentrum 1, 90471 Nuremberg, Germany.
Take the opportunity and visit POWTECH, the Leading Trade Fair for Powder & Bulk Solids Processing and Analytics, as well as FACHPACK, the European trade fair for packaging, technology and processing, taking place from 27 - 29 September 2022 in the exhibition center in Nuremberg.
A free entry ticket will be provided to all participants.
Phospholipids are excipients of natural origin that play several roles in the oral administration of drugs. With the growing number of drugs with poor water solubility, there is an increasing need for new formulation concepts that ensure effective dissolution or solubilization of these drugs in the gastrointestinal tract. At this point, phospholipids represent interesting excipient candidates for e.g. lipid-based, co-amorphous or micellar formulations. When it comes to best predicting the in vivo drug release of poorly soluble drug candidates based on in vitro release assays, phospholipids come back into play. Together with other physiologically relevant components, such as bile salts, their use in biorelevant dissolution media usually allows a
much better prediction of the in vivo release of poorly soluble drugs from their formulations. Finally, phospholipids also play a major role in drug absorption. As important cell membrane components, they are key determinants of the permeability of the gastrointestinal mucosa and therefore also influence the fraction of the orally administered drug dose that ultimately reaches the systemic circulation.
The aim of the workshop is to provide the participants with the latest knowledge on current phospholipid-based formulation concepts for small molecules and biological agents as well as on advanced and predictive in vitro methods for characterization of drug release and permeation.
Wednesday, September 28
PD Dr. habil. Simon Drescher (PRC Heidelberg, Germany) - Introduction in the use of phospholipids in pharmaceutical formulations
Prof. Dr. Sandra Klein (University of Greifswald, Germany) - The role of phospholipids in the development of in vitro assays to predict in vivo drug release
Prof. Dr. Anette Müllertz (University of Copenhagen, Denmark) - Phospholipid complexes in SNEDDS for increasing gastro-intestinal absorption of peptides
Dr. Paulina Skupin-Mrugalska (Poznan University of Medical Sciences, Poland) - Phospholipid/polymer mixtures as matrices for solid dispersions of poorly soluble drugs
Prof. Dr. Thomas Rades (University of Copenhagen) - Co-amorphous phospholipid drug complexes
Dr. Frank Karkossa (University of Greifswald, Germany) - Oral mixed micelle formulations—a novel phospholipid-based platform for safe and effective pediatric drug delivery
Thursday, September 29
N.N. - Natural phospholipids as pharmaceutical excipients − experiences from the pharmaceutical industry
Dr. Ann-Christin Jacobsen (Uppsala University, Sweden) - Phospholipids may boost or depress drug absorption: how to get the balance right
Dr. Meike van der Zande (Wageningen University, The Netherlands) - Evaluation of the properties of phospholipid-based nanocarriers for oral delivery using an in vitro test strategy
Prof. Dr. Martin Brandl (University of Southern Denmark, Odense, Denmark) - Latest additions to the in vitro toolbox for biopharmaceutical evaluation of enabling formulations